بررسی‌ اثرات‌ هیستوپاتولوژیکی‌ عصاره‌ سیر داخل‌ صفاقی بر کبد موش‌ صحرایی‌‌

In recent years, many investigations have reported the  pharmaceutical    effects of garlic such as antibacterial, antihypertension, antithrombotic,    anticarcinogenic and many others. Studies suggest that garlic may has    toxic effects on body tissues. In this study,  histopathological effects of garlic    extract on liver tissue in rats were investigated.           The animals were divided into five groups including control group     (received saline) and four experimental groups (received garlic extract, 50,    100, 200 and 400mg/kg intraperitonally for a month). The sections of liver    tissue were stained by H&E method for histopathological examination.           The histopathological examination indicated that administration of low    dose of garlic (50mg/Kg) has little effects on liver tissue in comparison with    the control animals. However, administration of high dose of garlic    (400mg/kg) induce considerable damage on this tissue in comparison to    other groups.           Although the use of garlic is useful for body, the consumption of high    levels of garlic may induce toxic effects on body tissues. Therefore, further    studies are needed before garlic preparations can be used as medicine.